منابع مشابه
The genetic landscape of anaplastic astrocytoma
Anaplastic astrocytoma WHO grade III (A3) is a lethal brain tumor that often occurs in middle aged patients. Clinically, it is challenging to distinguish A3 from glioblastoma multiforme (GBM) WHO grade IV. To reveal the genetic landscape of this tumor type, we sequenced the exome of a cohort of A3s (n=16). For comparison and to illuminate the genomic landscape of other glioma subtypes, we also ...
متن کاملAnaplastic astrocytoma post radiotherapy of pineal germinoma.
Dra. Martha Tena-Suck – Departamento de Neuropatología / Instituto Nacional de Neurología y Neurocirugía “Manuel Velasco Suárez” Av. Insurgentes Sur, 3788 Col. La fama, Delegación Tlalpan C.P. 14269 México DF México. E-mail: [email protected] Intracranial germ cell tumors (GCTs), especially pineal tumors have attracted the special attention of neuropathologists and neurosurgeons because of ...
متن کاملGenetic landscape of extreme responders with anaplastic oligodendroglioma
BACKGROUND The NRG Oncology RTOG 9402 trial showed significant survival benefit in patients with 1p/19q co-deleted anaplastic oligodendrogliomas (AO) who received both radiation (RT) and chemotherapy (PCV regimen) versus RT alone. Substantial separation of the survival curves was only seen after 7.3 years. We aimed to determine whether there are specific genetic alterations that distinguish co-...
متن کاملAcquired stuttering due to recurrent anaplastic astrocytoma.
Acquired (neurogenic) stuttering is a rare phenomenon seen after cerebral infarction or brain injury. Aetiology of this symptom is unclear, but recent evidence supports that it is a disturbance in the left hemispheric neural network involving the interplay between the cortex and basal ganglia. We present the case of a patient who develops acquired stuttering after a recurrence of a right tempor...
متن کاملBenefit with adjuvant chemotherapy in anaplastic astrocytoma.
www.thelancet.com Published online August 8, 2017 http://dx.doi.org/10.1016/S0140-6736(17)31477-0 1 The role of chemotherapy for newly diagnosed anaplastic gliomas, particularly when combined with radiotherapy, has long been unresolved. Over the past few decades, despite no conclusive data, study findings have suggested that the addition of nitrosourea-based chemotherapy to radiotherapy could b...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2013
ISSN: 1949-2553
DOI: 10.18632/oncotarget.1505